}

pyrimethamine (prescription) ** full range

(amalar, amalar forte, anitmala, antifocinc, croydoxin-fm, daraprim, falcistat, fansidar, laridox, laridox forte, malacide, malason, malex, malocide, metakelfin, pirimetamina labesfal, plasmodin, primet, pyralfin, pyrimethamine minsheng, pyrison, suldox, sulfadoxine-pyrimethamine indo farma, sulfamin)

Check for interactions on Supp.AI

Sources

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Correcting for drug impact

Related

Citizen Science Infered Impact

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

SymptomFrequency Found
Age: 30-40Worsen
Age: 60-70Improves
Autonomic Manifestations: irritable bowel syndromeWorsen
Autonomic Manifestations: light-headednessWorsen
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS)Improves
Autonomic Manifestations: urinary frequency dysfunctionImproves
Autonomic: Blurred or tunnel vision after standingWorsen
Autonomic: Dizziness or faintingWorsen
Autonomic: NauseaImproves
Autonomic: Shortness of breathWorsen
Blood Type: A PositiveWorsen
Blood Type: O PositiveImproves
Comorbid-Mouth: Dry MouthImproves
Comorbid-Mouth: Mouth SoresWorsen
Comorbid: High AnxietyWorsen
Comorbid: Histamine or Mast Cell issuesImproves
Comorbid: HypothyroidismImproves
Comorbid: Small intestinal bacterial overgrowth (SIBO)Worsen
Comorbid: Snoring (NOT Sleep ApneaWorsen
Gender: FemaleWorsen
Immune Manifestations: Abdominal PainImproves
Immune Manifestations: BloatingWorsen
Immune Manifestations: ConstipationWorsen
Immune Manifestations: DiarrheaImproves
Immune Manifestations: general malaiseImproves
Immune Manifestations: Mucus in the stoolWorsen
Immune Manifestations: new food sensitivitiesWorsen
Immune Manifestations: recurrent flu-like symptomsImproves
Immune: Recurrent Sore throatWorsen
Immune: Tender / sore lymph nodesWorsen
Immune: Viral infections with prolonged recovery periodsImproves
Infection: Parasite - OtherWorsen
Joint: Stiffness and swellingWorsen
Joint: Sudden and severe episodes of painWorsen
Joint: TendernessImproves
Neurocognitive: Brain FogImproves
Neurocognitive: Difficulty expressing thoughtsWorsen
Neurocognitive: Difficulty paying attention for a long period of timeWorsen
Neurocognitive: Difficulty understanding thingsWorsen
Neurocognitive: Problems remembering thingsWorsen
Neurocognitive: Slowness of thoughtWorsen
Neurocognitive: Unable to focus vision and/or attentionImproves
Neuroendocrine Manifestations: abnormal appetiteImproves
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome)Worsen
Neuroendocrine Manifestations: marked weight change Worsen
Neuroendocrine Manifestations: NeuralgiaWorsen
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin)Worsen
Neuroendocrine Manifestations: Rapid muscular fatiguabilityWorsen
Neuroendocrine Manifestations: subnormal body temperatureImproves
Neuroendocrine: Feeling like you have a low temperatureImproves
Neuroendocrine: Lack of appetiteImproves
Neuroendocrine: Lost or gained weight without tryingWorsen
Neuroendocrine: Temperature fluctuations throughout the dayWorsen
Neurological-Audio: Tinnitus (ringing in ear)Improves
Neurological-Sleep: Chaotic diurnal sleep rhythms (Irratic Sleep)Improves
Neurological-Sleep: Inability for deep (delta) sleepImproves
Neurological-Sleep: InsomniaWorsen
Neurological-Sleep: Vivid Dreams/NightmaresWorsen
Neurological-Vision: Blurred VisionImproves
Neurological-Vision: inability to focus eye/visionImproves
Neurological-Vision: photophobia (Light Sensitibity)Worsen
Neurological: Difficulty processing information (Understanding)Improves
Neurological: DysautonomiaImproves
Neurological: emotional overloadImproves
Neurological: fasciculations Improves
Neurological: High degree of Empathy before onsetImproves
Neurological: Joint hypermobilityWorsen
Official Diagnosis: Autoimmune DiseaseImproves
Official Diagnosis: Chronic Fatigue SyndromeImproves
Official Diagnosis: Mast Cell DysfunctionWorsen
Official Diagnosis: Ulcerative colitisWorsen
Onset: 2000-2010Improves
Onset: 2010-2020Improves
Onset: GradualImproves
Other: Sensitivity to moldWorsen
Other: Sensitivity to vibrationsImproves
Pain: Aching of the eyes or behind the eyesWorsen
Pain: Eye painWorsen
Pain: Joint painWorsen
Pain: Myofascial painWorsen
Pain: Sensitivity to painWorsen
Post-exertional malaise: Difficulty reading after mild physical or mental activityImproves
Post-exertional malaise: GeneralImproves
Post-exertional malaise: Mentally tired after the slightest effortImproves
Post-exertional malaise: Post-exertional malaiseWorsen
Post-exertional malaise: Rapid cognitive fatigability, Improves
Post-exertional malaise: Rapid muscular fatigability, Improves
Post-exertional malaise: Worsening of symptoms after mild mental activityImproves
Sleep: Daytime drowsinessImproves
Sleep: Need to nap dailyWorsen
Sleep: Problems staying asleepImproves

Published Science Infered Impact

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

SymptomFrequency Found
Hashimoto's thyroiditisImproves
Type 2 DiabetesWorsen
ADHDWorsen
Brain TraumaWorsen
Sjögren syndromeImproves
Stress / post-traumatic stress disorderImproves
Small Intestinal Bacterial Overgrowth (SIBO)Improves
AcneWorsen
Generalized anxiety disorderImproves
AsthmaWorsen
AtherosclerosisImproves
Crohn's DiseaseWorsen
Barrett esophagus cancerImproves
Chronic Fatigue SyndromeWorsen
Colorectal CancerImproves
Celiac DiseaseWorsen
Inflammatory Bowel DiseaseImproves
Type 1 DiabetesWorsen
Rheumatoid arthritisWorsen
EpilepsyWorsen
FibromyalgiaImproves
Functional constipation / chronic idiopathic constipationWorsen
GoutWorsen
Graves' diseaseImproves
Gastro-esophageal reflux disease (Gerd)Worsen
Non-Celiac Gluten SensitivityImproves
Histamine IssuesImproves
Irritable Bowel SyndromeImproves
IgA nephropathy (IgAN)Improves
DepressionWorsen
Parkinson's DiseaseWorsen
Chronic Kidney DiseaseWorsen
Systemic Lupus ErythematosusImproves
Liver CirrhosisWorsen
Non-alcoholic Fatty Liver Disease Improves
ME/CFS with IBSWorsen
ME/CFS without IBSWorsen
Amyotrophic lateral sclerosis (ALS) Motor NeuronWorsen
neuropsychiatric disorders (PANDAS, PANS)Worsen
High Blood PressureWorsen
PsoriasisImproves
Multiple SclerosisWorsen
Mood DisordersWorsen
rheumatoid arthritis (RA) and Spondyloarthritis (SpA)Improves
SchizophreniaWorsen
Ankylosing spondylitisImproves
AutismWorsen
Ulcerative colitisWorsen
AllergiesWorsen
SclerosisWorsen
Alzheimer's diseaseWorsen

Bacteria Impacted

}

The following are impacted (to sort click on column title)

Suggest a missed study:
Taxonomy Rank Effect Citations Links
Clostridiaceae family Decreases Source Study Bacteria also modified by
Coriobacteriaceae family Decreases Source Study Bacteria also modified by
Desulfovibrionaceae family Decreases Source Study Bacteria also modified by
Enterobacteraceae family Decreases Source Study Bacteria also modified by
Eubacteriaceae family Decreases Source Study Bacteria also modified by
Fusobacteriaceae family Decreases Source Study Bacteria also modified by
Lachnospiraceae family Decreases Source Study Bacteria also modified by
Peptostreptococcaceae family Decreases Source Study Bacteria also modified by
Porphyromonadaceae family Decreases Source Study Bacteria also modified by
Prevotellaceae family Decreases Source Study Bacteria also modified by
Ruminococcaceae family Decreases Source Study Bacteria also modified by
Streptococcaceae family Decreases Source Study Bacteria also modified by
Anaerobacter genus Decreases Source Study Bacteria also modified by
Bilophila genus Decreases Source Study Bacteria also modified by
Blautia genus Decreases Source Study Bacteria also modified by
Clostridioides genus Decreases Source Study Bacteria also modified by
Collinsella genus Decreases Source Study Bacteria also modified by
Coprococcus genus Decreases Source Study Bacteria also modified by
Dorea genus Decreases Source Study Bacteria also modified by
Escherichia genus Decreases Source Study Bacteria also modified by
Eubacterium genus Decreases Source Study Bacteria also modified by
Fusibacterium genus Decreases Source Study Bacteria also modified by
Kluyvera genus Decreases Source Study Bacteria also modified by
Parabacteroides genus Decreases Source Study Bacteria also modified by
Peptoclostridium genus Decreases Source Study Bacteria also modified by
Prevotella genus Decreases Source Study Bacteria also modified by
Roseburia genus Decreases Source Study Bacteria also modified by
Ruminococcus genus Decreases Source Study Bacteria also modified by
Streptococcus genus Decreases Source Study Bacteria also modified by
Bacillus coli species Decreases Source Study Bacteria also modified by
Bilophila wadsworthia species Decreases Source Study Bacteria also modified by
Clostridioides difficile species Decreases Source Study Bacteria also modified by
Collinsella aerofaciens species Decreases Source Study Bacteria also modified by
Corynebacterium fusiforme species Decreases Source Study Bacteria also modified by
Dorea formicigenerans species Decreases Source Study Bacteria also modified by
Photorhabdus asymbiotica species Decreases Source Study Bacteria also modified by
Porphyromonas levii species Decreases Source Study Bacteria also modified by
Ristella distasonis species Decreases Source Study Bacteria also modified by
Roseburia hominis species Decreases Source Study Bacteria also modified by
Ruminococcus flavefaciens species Decreases Source Study Bacteria also modified by

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