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The information on this site is from academic and research studies. Applicability to humans must be determined by a licensed medical professional.

Suggestions to counter the impact of trimethoprim antibiotics

US These are suggestions that should be reviewed by a medical professional familar with you before implementing. Some suggestions may have adverse reactions with some conditions. The suggestions are built from a logical model using published research on humans and animals. The suggestions may not be applicable to humans.

Click on the substance to see what it modifies. For probiotic sources click here

Items to increase or take

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Source: Prefered in bulk and organic, with make your own capsules
SubstanceProbability Estimate

Probiotic Mixtures

See this post on how to add more probiotic mixtures.

As always, probiotics should be reviewed by a knowledgable medical professional before starting.

Positive Impact

These have good impact with NO KNOWN RISK of bad impact. These should be your first choice

  1. spain (es) / ultralevura : impact 0.7
  2. naturopathica (au) / gastrohealth probiotics : impact 0.7
  3. spain (es) / axiboulardi : impact 0.7

Mixed Impact

You want the highest NET value (Take - Avoid), when there are several with similar values. Take the one with the lowest avoid value.

Ideally you want Take/Avoid to be a 2:1 or higher ratio.

Commercial Probiotic NameNetTakeAvoid
symbiopharm / symbioflo 2 18.5 19.8 1.3
spain (es) / alflorex -1.9 0.7 2.6
natren / life start 2 (goat milk-based) -1.9 0.7 2.6
spain (es) / muvagyn probiotico -2.7 2.6 5.3
mutaflor / mutaflor -4.6 11.9 16.5
microbiome labs/ megasporebiotic -5.3 1.3 6.6
vitamin angels / just thrive -5.9 0.7 6.6
microbiome labs / restorflora -5.9 0.7 6.6
organic 3 / primal soil -5.9 0.7 6.6
reserveage nutrition / beautiflora -5.9 0.7 6.6
amy meyers / primal earth probiotic -5.9 0.7 6.6
enviromedica terraflora sbo probiotic -5.9 0.7 6.6
corebiotic -5.9 0.7 6.6
klaire labs / biospora -5.9 0.7 6.6
microbiome labs /hu58 -5.9 0.7 6.6
perfect pass / perfect pass probiotic bacillus spore -5.9 0.7 6.6
global health trax / threelac -5.9 0.7 6.6
bio-botanical research / proflora4r restorative probiotic -5.9 0.7 6.6
nature's instincts / ultra spore probiotic -5.9 0.7 6.6
o'donnell / flora-balance -17.1 0.7 17.8
blackmore (au) / probiotics+ eczema relief -17.8 4 21.8
activia drink -21.1 1.3 22.4
natren / megadophilus -22.4 2 24.4
quality health (au) / fridge free* probiotic 60s -22.4 2 24.4
bayer / trubiotics daily probiotic -23.7 2 25.7
trubiotics / one a day -23.7 2 25.7
spain (es) / suerobivos -23.8 2.6 26.4
culturelle / culturelle -23.8 2.6 26.4
spain (es) / bivos -23.8 2.6 26.4
spain (es) / ns defenbiotic kids -23.8 2.6 26.4
spain (es) / kaleidon -23.8 2.6 26.4
digestive care -23.8 2.6 26.4
optibac / for those on antibiotics -25.1 3.3 28.4
bioflorin (deu) / bioflorin -26.4 2 28.4
spain (es) / ns florabiotic instant -26.4 4 30.4
miyarisan (jp) / miyarisan -27.1 1.3 28.4
optibac / for daily immunity -27 2 29
custom probiotics / d-lactate free probiotics powder -27 4 31
spain (es) / gastrus -27 4 31
spain (es) / reuteri gotas -27 4 31
spain (es) / casenbiotic -27 4 31
spain (es) / gum periobalance -27 4 31
naturopathica (au) / gastrohealth antacid -27.7 1.3 29
danactive drink -27.7 1.3 29
anabolic laboratories / probiotic complete -29.7 2.6 32.3
jarrow formulas / fem dophilus -29.7 5.3 35
spain (es) / aquilea intimus -29.7 5.3 35
blackmore (au) / probiotics+ womens flora balance -29.7 5.3 35
optibac / for women -29.7 5.3 35
jarrow formulas / fem-dophilus® -29.7 5.3 35
quality health(au)/ fridge free probiotic 25b -31 2 33
canada (ca) / calmbiotic -31.6 0.7 32.3
mwsb / candida yeast support -32.4 2.6 35
naturopathica (au)/ gastrohealth probiotic daily care -32.4 2.6 35
powerlabs (au) / ultra blend -32.4 2.6 35
bioglan bio (au/ happy probiotic 25 -33.7 3.3 37
bioglan (au) / healthy kids probiotic choc balls 50s -33.7 3.3 37
nature's way (au) / restore probiotic choc balls 60s -33.7 3.3 37
jarrow formulas / jarro-dophilus mood -34.3 2 36.3
solgar / advanced acidophilus plus -35 3.3 38.3
naturopathica (au) / gastrohealth fibrepro -37.6 4.6 42.2
optibac / bifidobacteria & fibre -40.3 4.6 44.9
optibac / for every day max -43.6 3.3 46.9
aor / probiotic-3 -44.2 5.3 49.5
naturopathica (au) / gastrohealth probiotic adults 50+ -46.8 5.3 52.1
jarrow formulas / bifidus balance® + fos -48.1 7.3 55.4
nature's way (au) / restore probiotic daily health 90s -48.9 5.9 54.8
nature's way (au) / restore probiotic 30 billion 30s -48.9 5.9 54.8
bravo europe / freeze-dried bravo -60.1 4.6 64.7
naturopathica (au) / gastrohealth women’s probiotic with cranberry -63.3 8.6 71.9
natren / bifido factor -66.6 5.3 71.9
bio-k+ -75.9 7.9 83.8
blackmores (au) / probiotics + adults daily (90 capsules) -76.5 7.3 83.8
blackmore (au) / probiotics+ daily health -76.5 7.3 83.8
philips / colon health -77.2 7.3 84.5
wakamoto (jp) / wakamoto pharmaceutical intestinal drug -77.2 7.3 84.5
just for tummies / live bacteria -77.2 7.9 85.1
custom probiotics / b. lactis & b. bifidum probiotic powder -77.9 6.6 84.5
solgar / advanced multi-billion dophilus -86.4 7.3 93.7
solgar / advanced 40+ acidophilus -86.4 7.3 93.7
shin biofermin (jp) /s -89.1 7.3 96.4
custom probiotics / five strain bifidobacteria -89.1 7.9 97
natren / healthy trinity probiotic -94.3 7.3 101.6
klaire labs / ther-biotic factor 4 -97 7.3 104.3
gnc / ultra probiotic complex -100.3 8.6 108.9
cytoplan(uk) /dentavital bifidophilus -103 9.9 112.9
optibac / for your cholesterol -107.6 9.9 117.5
genestra brands® hm -108.9 8.6 117.5
spain (es) / profaes4 viajeros -108.9 8.6 117.5
spain (es) / profaes4 edad escolar -108.9 8.6 117.5
biospec / probiotic-5 -111.5 10.6 122.1
speer labs / emuaid first defense -115.5 9.2 124.7
blackmore (au) / probiotics+ bowel support -116.1 11.9 128
spain (es) / l3.1 -120.1 9.9 130
optibac / for every day -121.5 12.5 134
blackmores (au) / probiotics+ immune defence -122.8 11.2 134
nature's bounty / probioti 10 -128.1 9.2 137.3
jamieson (can) / probiotic 10 bcfu -130.6 10.6 141.2
custom probiotics / four strain lactobacilli -134 12.5 146.5
zint nutrition / probiotic collagen + -145.8 13.9 159.7
up4 /women's -145.8 15.2 161
bravo europe / starter and complex -147.9 12.5 160.4
naturopathica (au) / gastrohealth probiotic dairy free 20 bcfu -157.1 15.2 172.3
klaire labs / target gb-x -160.4 13.2 173.6
nature's way (au) /restore probiotic bowel & colon health 30s -168.3 16.5 184.8
naturopathica (au) /gastrohealth probiotic ultimate daily care 100billion -170.9 15.2 186.1
spain (es) / vivomixx -176.2 13.9 190.1
Realdose -178.2 15.2 193.4
probiotic pur (de) / realdose nutrition -178.9 15.8 194.7
seed / male version -184.2 19.1 203.3
lifted naturals / mood boosting probiotic -185.4 15.2 200.6
naturopathica (au) / gastrohealth probiotic dairy free 50 billion -186.1 17.8 203.9
ferring / vsl#3 -188.1 12.5 200.6
jarrow formulas / jarro-dophilus eps -196.1 15.8 211.9
vinco / probiotic eight 65 -197.3 18.5 215.8
jarrow formula / jarro-dophilus original -198 18.5 216.5
visbiome -199.3 17.2 216.5
organic 3 / gutpro -206.6 18.5 225.1
custom probiotics / six strain probiotic powder -211.9 19.1 231
fairvital / microflora basic -217.8 18.5 236.3
up4 / adult -219.1 18.5 237.6
seed / female version -221.7 21.8 243.5
young living/life 9 -222.4 19.8 242.2
bioglan bio (au) / happy probiotic 50 -223.1 19.8 242.9
jarrow formulas / jarro-dophilus® ultra -246.2 19.8 266
udo's choice /super 8 gold -262 23.1 285.1
1 md / complete probiotics platinum -278.6 25.7 304.3
solaray / mycrobiome probiotic colon formula -282.4 23.8 306.2
theramedix / probiotic -283.2 24.4 307.6
fürstenmed / lacto-bifido -284.5 24.4 308.9
quantum wellness / restora flora -298.4 25.7 324.1
renew life men's probiotic - ultimate -299 25.1 324.1
up4 / ultra -300.3 25.7 326
bioglan bio (au) / happy probiotic 100 -300.3 26.4 326.7
douglas laboratories / multi probiotic 40 billion -304.3 26.4 330.7
renew life / ultimate flora -306.3 25.7 332
garden of life / primal defense -306.9 26.4 333.3
bioray / cytoflora -309.6 27.7 337.3
organic 3 / primal gut -310.2 27.7 337.9
elixa / probiotic -320.1 28.4 348.5
hyperbiotics / pro-15 -334.6 31.7 366.3
newrhythm / probiotics 20 stains -355.1 31.7 386.8
vita miracle / ultra-30 probiotics -359.1 31 390.1
nature's way (au) / restore probiotic 100 billion -360.4 29.7 390.1

Negative Impact

  1. reg'activ / immune & vitality
  2. spain (es) / lactanza hereditum
  3. natren / digesta-lac
  4. wakamoto (jp) / strong wakamoto w

No Known Impact

These appear to have no known direct impact. There is no reason to discontinue them if you are talking them

  1. align / align
  2. daiichi sankyo healthcare (jp) / panlacmin tablet
  3. enterogermina
  4. florastor / florastor
  5. goodbelly drink
  6. hyperbiotics / pro-dental
  7. jarrow formula / ideal bowel support® lp299v®
  8. nature's way (au) / adult vita gummies daily probiotic 80s
  9. optibac / saccharomyces boulardii
  10. organic 3 / yeastbiotic
  11. probiotic 3
  12. schiff / digestive advantage
  13. source naturals / duraflora
  14. symbiopharm / symbioflor 1
  15. thorne / bacillus coagulansvet 60 caps

Flavonoid Foods Suggested

These are a net positive impact -- Odds are that the dominant flavonoids are what is helping. They may be in other foods that have not been studied. Explore!

Flavonoids Suggested

These are a net positive impact -- see what foods they are in (the higher the better!)

Why "Source: Prefered in bulk and organic, with make your own capsules". First, few pre-capsulized supplements are organic, most have fillers and the cost per gram as prepared capsules can be 4x to 50x higher than in bulk. Many folks have reported things did not help until they change to a different brand with different fillers.

Items to decrease or stop

SubstanceProbability Estimate
oregano (origanum vulgare, oil) | 1
thyme 0.947
syzygium aromaticum (clove) 0.882
lactobacillus plantarum (probiotics) 0.877
foeniculum vulgare (Fennel) 0.594
ginger 0.545
cinnamon (oil. spice) 0.535
bifidobacterium bifidum (probiotics) 0.529
triphala 0.519
turmeric (curcuma longa, Curcumin) 0.508
rosmarinus officinalis (rosemary) 0.412
lactobacillus casei (probiotics) 0.412
nigella sativa seed (black cumin) 0.396
fennel 0.364
garlic (allium sativum) 0.342
coriander oil 0.316

Contradictory Suggestions

I have seen lactobacillus rhamnosus gg (probiotics) being a TO TAKE and lactobacillus rhamnosus (probiotics) is to avoid. Why? Different studies have different results. Sometimes it is because of other factors (study done on healthy people in one case, on overweight people in the other case). One study may have measured the bacteria you are high in, the other did not. Similarly, one study may have measured the bacteria you are low in, the other did not. There is a forest of qualifications that are nearly impossibly complex to address, and if you try, it will often lack an objective decision that can be demonstrated ("I think...."). Where there are 'conflicts', my usual advice is to just omit it entirely from consideration. If you are taking it, keep taking it. It not, don't.


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