}

Suggestions to counter the impact of mercaptopurine (prescription)

US These are suggestions that should be reviewed by a medical professional familar with you before implementing. Some suggestions may have adverse reactions with some conditions. The suggestions are built from a logical model using published research on humans and animals. The suggestions may not be applicable to humans.

Click on the substance to see what it modifies. For probiotic sources click here

Items to increase or take

;
Source: Prefered in bulk and organic, with make your own capsules
SubstanceProbability Estimate
inulin (prebiotic) ; 0.689
arabinoxylan oligosaccharides (prebiotic) ; 0.628
resistant starch ; 0.561
resveratrol (grape seed/polyphenols/red wine) ; 0.556
almonds/ almond skins ; 0.4
lactulose ; 0.389
ketogenic diet ; 0.372
sesame cake/meal ; 0.367
daesiho-tang ; 0.367
Slippery Elm ; 0.361
red wine ; 0.333
magnesium ; 0.317
Vitamin B9 (Folate) ; 0.317
saccharomyces boulardii (probiotics) ; 0.3

Probiotic Mixtures

See this post on how to add more probiotic mixtures.

As always, probiotics should be reviewed by a knowledgable medical professional before starting.

Positive Impact

These have good impact with NO KNOWN RISK of bad impact. These should be your first choice

  1. reg'activ / immune & vitality : impact 2.6
  2. Pädia GmbH (DE)/Mambiotic Kapseln : impact 2.6
  3. spain (es) / lactanza hereditum : impact 2.6
  4. enterogermina : impact 1.3

Mixed Impact

You want the highest NET value (Take - Avoid), when there are several with similar values. Take the one with the lowest avoid value.

Ideally you want Take/Avoid to be a 2:1 or higher ratio.

Commercial Probiotic NameNetTakeAvoid
nature's way (au) /restore probiotic bowel & colon health 30s 37.4 82.5 45.1
naturopathica (au) / gastrohealth probiotic dairy free 50 billion 37 94.2 57.2
naturopathica (au) / gastrohealth probiotic dairy free 20 bcfu 35.4 73.9 38.5
naturopathica (au) / gastrohealth fibrepro 33.9 47.3 13.4
nature's way (au) / restore probiotic daily health 90s 33.9 52.6 18.7
nature's way (au) / restore probiotic 30 billion 30s 33.9 52.6 18.7
jarrow formulas / bifidus balance® + fos 33.9 65.1 31.2
blackmore (au) / probiotics+ eczema relief 33 44.4 11.4
theramedix / probiotic 31.5 103 71.5
blackmores (au) / probiotics+ immune defence 29.2 65.1 35.9
probiotic pur (de) / realdose nutrition 27.7 74.8 47.1
blackmores (au) / probiotics + adults daily (90 capsules) 26 57.2 31.2
blackmore (au) / probiotics+ daily health 26 57.2 31.2
blackmore (au) / probiotics+ bowel support 24.2 62.5 38.3
Realdose 21.8 68.9 47.1
lifted naturals / mood boosting probiotic 17.1 64 46.9
spain (es) / ultralevura 15 16.5 1.5
spain (es) / axiboulardi 15 16.5 1.5
naturopathica (au) / gastrohealth probiotic adults 50+ 15 34.1 19.1
nature's instincts / ultra spore probiotic 13.9 18.5 4.6
zint nutrition / probiotic collagen + 13.8 48.8 35
optibac / for every day 13.2 57.4 44.2
up4 /women's 13 53.5 40.5
optibac / for those on antibiotics 12.3 22.2 9.9
florastor / florastor 11.8 12.5 0.7
optibac / saccharomyces boulardii 11.8 12.5 0.7
organic 3 / yeastbiotic 11.8 12.5 0.7
microbiome labs / restorflora 11.9 15.2 3.3
custom probiotics / four strain lactobacilli 11.9 46.9 35
optibac / bifidobacteria & fibre 11.5 33.9 22.4
Jetson / FIT 11.2 26.4 15.2
naturopathica (au) /gastrohealth probiotic ultimate daily care 100billion 9.7 59.4 49.7
optibac / for every day max 9.2 24.4 15.2
spain (es) / ns defenbiotic kids 9.1 21.6 12.5
biospec / probiotic-5 8.5 38.9 30.4
quality health(au)/ fridge free probiotic 25b 7.9 19.8 11.9
naturopathica (au)/ gastrohealth probiotic daily care 7.5 20.9 13.4
optibac / for your cholesterol 7.5 27.3 19.8
spain (es) / l3.1 7.5 28.6 21.1
seed / male version 6.8 65.8 59
natren / megadophilus 6.6 12.5 5.9
CustomProbiotics.com / L. Acidophilus Probiotic Powder 6.6 12.5 5.9
quality health (au) / fridge free* probiotic 60s 6.6 12.5 5.9
bioglan bio (au/ happy probiotic 25 6.6 17.8 11.2
bioglan (au) / healthy kids probiotic choc balls 50s 6.6 17.8 11.2
nature's way (au) / restore probiotic choc balls 60s 6.6 17.8 11.2
solgar / advanced acidophilus plus 6.6 17.8 11.2
young living/life 9 6 64.7 58.7
CustomProbiotics.com / L. Rhamnosus Probiotic Powder 5.7 9.7 4
custom probiotics / d-lactate free probiotics powder 5.7 26.8 21.1
symbiopharm / symbioflo 2 4.9 5.3 0.4
spain (es) / muvagyn probiotico 4.8 14.3 9.5
bayer / trubiotics daily probiotic 4.6 13.2 8.6
trubiotics / one a day 4.6 13.2 8.6
jarrow formulas / jarro-dophilus mood 4.4 16.9 12.5
bio-k+ 4.4 30.8 26.4
cytoplan(uk) /dentavital bifidophilus 4.4 37.4 33
jarrow formula / jarro-dophilus original 4.4 60.5 56.1
microbiome labs/ megasporebiotic 3.9 9.2 5.3
anabolic laboratories / probiotic complete 4 15.2 11.2
custom probiotics / six strain probiotic powder 4 58.1 54.1
vinco / probiotic eight 65 3.9 60.7 56.8
Jetson (US) / Mood Probiotics 3.7 17.6 13.9
nature's way (au) / adult vita gummies daily probiotic 80s 3.3 4.6 1.3
align / align 3.3 4.6 1.3
source naturals / duraflora 3.3 4.6 1.3
thorne / bacillus coagulansvet 60 caps 3.3 4.6 1.3
schiff / digestive advantage 3.3 4.6 1.3
daiichi sankyo healthcare (jp) / panlacmin tablet 3.3 4.6 1.3
activia drink 3.3 11.9 8.6
spain (es) / ns florabiotic instant 3.3 17.8 14.5
naturopathica (au) / gastrohealth women’s probiotic with cranberry 3.3 35.9 32.6
naturopathica (au) / gastrohealth probiotics 3.1 4 0.9
up4 / adult 2.9 51.7 48.8
powerlabs (au) / ultra blend 2.6 19.8 17.2
just for tummies / live bacteria 2.5 31.5 29
vitamin angels / just thrive 1.9 5.9 4
organic 3 / primal soil 1.9 5.9 4
reserveage nutrition / beautiflora 1.9 5.9 4
enviromedica terraflora sbo probiotic 1.9 5.9 4
corebiotic 1.9 5.9 4
klaire labs / biospora 1.9 5.9 4
perfect pass / perfect pass probiotic bacillus spore 1.9 5.9 4
global health trax / threelac 1.9 5.9 4
bio-botanical research / proflora4r restorative probiotic 1.9 5.9 4
genestra brands® hm 2 30.4 28.4
spain (es) / profaes4 viajeros 2 30.4 28.4
spain (es) / profaes4 edad escolar 2 30.4 28.4
jarrow formula / ideal bowel support® lp299v® 1.5 21.3 19.8
CustomProbiotics.com / L. Plantarum Probiotic Powder 1.5 21.3 19.8
1 md / complete probiotics platinum 1.1 82.5 81.4
CustomProbiotics.com / B. Longum Probiotic Powder 0.7 7.3 6.6
bravo europe / freeze-dried bravo 0.4 30.8 30.4
Nu U (uk) /Bio-Cultures Complex 0.4 32.1 31.7
spain (es) / vivomixx 0.2 47.7 47.5
visbiome 0.2 51.7 51.5
amy meyers / primal earth probiotic 0 2.6 2.6
microbiome labs /hu58 0 2.6 2.6
CustomProbiotics.com / B. Lactis Probiotic Powder 0 5.3 5.3
jarrow formulas / jarro-dophilus eps -0.2 50.6 50.8
ferring / vsl#3 -0.4 45.8 46.2
wakamoto (jp) / strong wakamoto w -0.7 4.6 5.3
CustomProbiotics.com / L. Gasseri Probiotic Powder -0.9 4.6 5.5
o'donnell / flora-balance -1.3 1.3 2.6
canada (ca) / calmbiotic -1.3 7.3 8.6
gnc / ultra probiotic complex -1.3 23.8 25.1
CustomProbiotics.com / B. Breve Probiotic Powder -1.9 0.7 2.6
CustomProbiotics.com / L. Salivarius Probiotic Powder -2 3.3 5.3
optibac / for daily immunity -1.9 10.6 12.5
klaire labs / ther-biotic factor 4 -2 24.4 26.4
bioglan bio (au) / happy probiotic 50 -2 62 64
miyarisan (jp) / miyarisan -2.2 3.3 5.5
spain (es) / suerobivos -2.5 8.1 10.6
culturelle / culturelle -2.5 8.1 10.6
spain (es) / bivos -2.5 8.1 10.6
spain (es) / kaleidon -2.5 8.1 10.6
digestive care -2.5 8.1 10.6
CustomProbiotics.com / B. Infantis Probiotic Powder -2.7 2.6 5.3
spain (es) / alflorex -2.7 2.6 5.3
natren / life start 2 (goat milk-based) -2.7 2.6 5.3
mutaflor / mutaflor -3.3 2.6 5.9
jarrow formulas / fem dophilus -3.3 18 21.3
spain (es) / aquilea intimus -3.3 18 21.3
blackmore (au) / probiotics+ womens flora balance -3.3 18 21.3
optibac / for women -3.3 18 21.3
jarrow formulas / fem-dophilus® -3.3 18 21.3
shin biofermin (jp) /s -3.3 19.1 22.4
natren / healthy trinity probiotic -3.3 19.1 22.4
udo's choice /super 8 gold -3.3 68.6 71.9
mwsb / candida yeast support -3.5 9.9 13.4
bravo europe / starter and complex -3.6 49.9 53.5
solgar / advanced multi-billion dophilus -3.7 30.6 34.3
solgar / advanced 40+ acidophilus -3.7 30.6 34.3
organic 3 / gutpro -3.9 55.7 59.6
ASEA VIA / BIOME -4.2 77.9 82.1
Jetson / Gut Prep -4.8 3.3 8.1
jamieson (can) / probiotic 10 bcfu -4.9 43.3 48.2
seed / female version -5.3 70.4 75.7
bioflorin (deu) / bioflorin -5.5 4 9.5
custom probiotics / five strain bifidobacteria -5.9 19.8 25.7
aor / probiotic-3 -6.1 11.9 18
Seeking Health / Probiota HistaminX -6.4 44.4 50.8
up4 / ultra -7.2 74.6 81.8
jarrow formulas / jarro-dophilus® ultra -7.5 68.4 75.9
solaray / mycrobiome probiotic colon formula -7.5 75.2 82.7
organic 3 / primal gut -7.5 91.1 98.6
CustomProbiotics.com / L. Paracasei Probiotic Powder -7.9 4.6 12.5
naturopathica (au) / gastrohealth antacid -7.9 4.6 12.5
danactive drink -7.9 4.6 12.5
CustomProbiotics.com / L. Casei Probiotic Powder -7.9 8.6 16.5
custom probiotics / b. lactis & b. bifidum probiotic powder -7.9 11.2 19.1
nature's bounty / probioti 10 -7.9 40.9 48.8
klaire labs / target gb-x -8 42.2 50.2
philips / colon health -8.2 17.8 26
wakamoto (jp) / wakamoto pharmaceutical intestinal drug -8.2 17.8 26
speer labs / emuaid first defense -8.8 23.1 31.9
quantum wellness / restora flora -8.8 84.5 93.3
spain (es) / gastrus -9 8.4 17.4
spain (es) / reuteri gotas -9 8.4 17.4
spain (es) / casenbiotic -9 8.4 17.4
CustomProbiotics.com / L. Reuteri Probiotic Powder -9 8.4 17.4
spain (es) / gum periobalance -9 8.4 17.4
renew life / ultimate flora -9.2 77.9 87.1
garden of life / primal defense -9.3 80.5 89.8
nature's way (au) / restore probiotic 100 billion -9.2 94.2 103.4
customprobiotics.com / B. Bifidum Probiotic Powder -9.9 6.6 16.5
natren / bifido factor -9.9 6.6 16.5
bioglan bio (au) / happy probiotic 100 -9.9 79.9 89.8
ecology_allergycare -11.3 35.6 46.9
elixa / probiotic -12.3 81.6 93.9
bioray / cytoflora -14.9 79 93.9
vita miracle / ultra-30 probiotics -15.2 98.1 113.3
renew life men's probiotic - ultimate -15.6 70.2 85.8
fürstenmed / lacto-bifido -16.5 67.3 83.8
douglas laboratories / multi probiotic 40 billion -16.5 74.8 91.3
fairvital / microflora basic -16.8 45.5 62.3
hyperbiotics / pro-15 -17.1 95.5 112.6
Winclove Probiotics / Ecologic®825 -17.6 61.6 79.2
newrhythm / probiotics 20 stains -20 95.5 115.5
Jetson (US) / Immunity Probiotics -26.2 45.3 71.5

No Known Impact

These appear to have no known direct impact. There is no reason to discontinue them if you are talking them

  1. CustomProbiotics.com / L. Brevis Probiotic Powder
  2. CustomProbiotics.com / L. Bulgaricus Probiotic Powder
  3. CustomProbiotics.com / L. Lactis Probiotic Powder
  4. CustomProbiotics.com / S. Thermophilus Probiotic Powder
  5. goodbelly drink
  6. hyperbiotics / pro-dental
  7. natren / digesta-lac
  8. probiotic 3
  9. symbiopharm / symbioflor 1

Flavonoid Foods Suggested

These are a net positive impact -- Odds are that the dominant flavonoids are what is helping. They may be in other foods that have not been studied. Explore!

Flavonoids Suggested

These are a net positive impact -- see what foods they are in (the higher the better!)

Why "Source: Prefered in bulk and organic, with make your own capsules". First, few pre-capsulized supplements are organic, most have fillers and the cost per gram as prepared capsules can be 4x to 50x higher than in bulk. Many folks have reported things did not help until they change to a different brand with different fillers.

Items to decrease or stop

SubstanceProbability Estimate
thiamine hydrochloride (vitamin B1) 1
Cyanocobalamin (Vitamin B-12) 0.983
retinoic acid (Vitamin A derivative) 0.967
Arbutin (polyphenol) 0.967
diosmin (polyphenol) 0.967
folic acid (supplement Vitamin B9) 0.967
Hesperidin (polyphenol) 0.967
pyridoxine hydrochloride (vitamin B6) 0.967
Guaiacol (polyphenol) 0.967
N-Acetyl Cysteine (NAC) 0.967
caffeine (coffee or non-herbal tea) 0.933
vitamin b3 (niacin) 0.933
vitamin b7 biotin (supplement) (vitamin B7) 0.933
luteolin (flavonoid) 0.917
melatonin supplement 0.867
Vitamin C (ascorbic acid) 0.867
aspirin (acetylsalicylic acid) 0.833
garlic (allium sativum) 0.383
chitosan (sugar) 0.317

Contradictory Suggestions

I have seen lactobacillus rhamnosus gg (probiotics) being a TO TAKE and lactobacillus rhamnosus (probiotics) is to avoid. Why? Different studies have different results. Sometimes it is because of other factors (study done on healthy people in one case, on overweight people in the other case). One study may have measured the bacteria you are high in, the other did not. Similarly, one study may have measured the bacteria you are low in, the other did not. There is a forest of qualifications that are nearly impossibly complex to address, and if you try, it will often lack an objective decision that can be demonstrated ("I think...."). Where there are 'conflicts', my usual advice is to just omit it entirely from consideration. If you are taking it, keep taking it. It not, don't.


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