Suggestions to counter the impact of bosentan (prescription)

US These are suggestions that should be reviewed by a medical professional familar with you before implementing. Some suggestions may have adverse reactions with some conditions. The suggestions are built from a logical model using published research on humans and animals. The suggestions may not be applicable to humans.

Click on the substance to see what it modifies. For probiotic sources click here

Items to increase or take

;
Source: Prefered in bulk and organic, with make your own capsules
SubstanceProbability Estimate
inulin (prebiotic) ; 0.574
arabinoxylan oligosaccharides (prebiotic) ; 0.554
resveratrol (grape seed/polyphenols/red wine) ; 0.461
resistant starch ; 0.417
lactulose ; 0.392
ketogenic diet ; 0.387
almonds/ almond skins ; 0.353
red wine ; 0.338
sesame cake/meal ; 0.324
daesiho-tang ; 0.324

Probiotic Mixtures

See this post on how to add more probiotic mixtures.

As always, probiotics should be reviewed by a knowledgable medical professional before starting.

Positive Impact

These have good impact with NO KNOWN RISK of bad impact. These should be your first choice

  1. Pädia GmbH (DE)/Mambiotic Kapseln : impact 2.6
  2. spain (es) / lactanza hereditum : impact 2.6
  3. enterogermina : impact 1.3

Mixed Impact

You want the highest NET value (Take - Avoid), when there are several with similar values. Take the one with the lowest avoid value.

Ideally you want Take/Avoid to be a 2:1 or higher ratio.

Commercial Probiotic NameNetTakeAvoid
nature's way (au) /restore probiotic bowel & colon health 30s 39.4 85.8 46.4
naturopathica (au) / gastrohealth probiotic dairy free 50 billion 37.8 97 59.2
naturopathica (au) / gastrohealth probiotic dairy free 20 bcfu 36.1 75.9 39.8
probiotic pur (de) / realdose nutrition 34.3 81.6 47.3
naturopathica (au) / gastrohealth fibrepro 33.3 48 14.7
nature's way (au) / restore probiotic daily health 90s 33.2 53.2 20
nature's way (au) / restore probiotic 30 billion 30s 33.2 53.2 20
theramedix / probiotic 31.3 107.6 76.3
blackmore (au) / probiotics+ eczema relief 30.3 43.1 12.8
jarrow formulas / bifidus balance® + fos 28.6 63.1 34.5
Realdose 28.4 75.7 47.3
blackmores (au) / probiotics + adults daily (90 capsules) 26.6 58.5 31.9
blackmore (au) / probiotics+ daily health 26.6 58.5 31.9
blackmores (au) / probiotics+ immune defence 26.6 65.8 39.2
blackmore (au) / probiotics+ bowel support 19.6 61.2 41.6
lifted naturals / mood boosting probiotic 18.5 66.7 48.2
naturopathica (au) / gastrohealth probiotic adults 50+ 16.1 35.2 19.1
nature's instincts / ultra spore probiotic 15.7 20.5 4.8
up4 /women's 15.4 55.9 40.5
spain (es) / ultralevura 14.9 17.8 2.9
spain (es) / axiboulardi 14.9 17.8 2.9
zint nutrition / probiotic collagen + 14.9 49.9 35
microbiome labs / restorflora 13.9 17.2 3.3
custom probiotics / four strain lactobacilli 13.6 48.6 35
florastor / florastor 13.2 13.9 0.7
optibac / saccharomyces boulardii 13.2 13.9 0.7
organic 3 / yeastbiotic 13.2 13.9 0.7
Jetson / FIT 12.5 27.9 15.4
optibac / for those on antibiotics 12.1 22 9.9
naturopathica (au) /gastrohealth probiotic ultimate daily care 100billion 12.1 62.5 50.4
optibac / for every day max 10.1 25.3 15.2
optibac / for every day 9.7 57.9 48.2
biospec / probiotic-5 9.2 39.8 30.6
quality health(au)/ fridge free probiotic 25b 8.8 20.7 11.9
optibac / for your cholesterol 8.8 28.6 19.8
spain (es) / l3.1 8.8 29.9 21.1
optibac / bifidobacteria & fibre 8.8 33.2 24.4
spain (es) / ns defenbiotic kids 8 20.5 12.5
natren / megadophilus 7.5 13.4 5.9
CustomProbiotics.com / L. Acidophilus Probiotic Powder 7.5 13.4 5.9
quality health (au) / fridge free* probiotic 60s 7.5 13.4 5.9
bioglan bio (au/ happy probiotic 25 7.5 18.7 11.2
bioglan (au) / healthy kids probiotic choc balls 50s 7.5 18.7 11.2
nature's way (au) / restore probiotic choc balls 60s 7.5 18.7 11.2
solgar / advanced acidophilus plus 7.5 18.7 11.2
vinco / probiotic eight 65 7 63.8 56.8
young living/life 9 7.1 67.8 60.7
custom probiotics / d-lactate free probiotics powder 6.6 27.7 21.1
naturopathica (au)/ gastrohealth probiotic daily care 6.4 21.1 14.7
seed / male version 6 68.9 62.9
jarrow formula / jarro-dophilus original 5.7 61.8 56.1
bayer / trubiotics daily probiotic 5.5 14.1 8.6
trubiotics / one a day 5.5 14.1 8.6
bio-k+ 5.5 31.9 26.4
spain (es) / muvagyn probiotico 5 14.5 9.5
spain (es) / vivomixx 5 51.9 46.9
visbiome 5 56.5 51.5
symbiopharm / symbioflo 2 4.9 5.3 0.4
anabolic laboratories / probiotic complete 4.9 16.1 11.2
CustomProbiotics.com / L. Rhamnosus Probiotic Powder 4.6 8.6 4
jarrow formulas / jarro-dophilus mood 4.7 17.2 12.5
1 md / complete probiotics platinum 4.6 88.2 83.6
microbiome labs/ megasporebiotic 4.4 9.9 5.5
up4 / adult 4.4 55.2 50.8
spain (es) / ns florabiotic instant 4.2 18.7 14.5
custom probiotics / six strain probiotic powder 3.7 59.8 56.1
just for tummies / live bacteria 3.6 32.6 29
cytoplan(uk) /dentavital bifidophilus 3.5 38.5 35
activia drink 3.3 11.9 8.6
Jetson (US) / Mood Probiotics 3.3 17.2 13.9
nature's way (au) / adult vita gummies daily probiotic 80s 3.1 4.6 1.5
align / align 3.1 4.6 1.5
source naturals / duraflora 3.1 4.6 1.5
thorne / bacillus coagulansvet 60 caps 3.1 4.6 1.5
schiff / digestive advantage 3.1 4.6 1.5
daiichi sankyo healthcare (jp) / panlacmin tablet 3.1 4.6 1.5
powerlabs (au) / ultra blend 3 20.2 17.2
ferring / vsl#3 3.1 48.6 45.5
jarrow formula / ideal bowel support® lp299v® 2.9 22.7 19.8
CustomProbiotics.com / L. Plantarum Probiotic Powder 2.9 22.7 19.8
vitamin angels / just thrive 2.4 6.6 4.2
organic 3 / primal soil 2.4 6.6 4.2
reserveage nutrition / beautiflora 2.4 6.6 4.2
enviromedica terraflora sbo probiotic 2.4 6.6 4.2
corebiotic 2.4 6.6 4.2
klaire labs / biospora 2.4 6.6 4.2
perfect pass / perfect pass probiotic bacillus spore 2.4 6.6 4.2
global health trax / threelac 2.4 6.6 4.2
bio-botanical research / proflora4r restorative probiotic 2.4 6.6 4.2
bravo europe / freeze-dried bravo 2.2 31.9 29.7
CustomProbiotics.com / B. Longum Probiotic Powder 2 8.6 6.6
naturopathica (au) / gastrohealth probiotics 1.8 4 2.2
bioglan bio (au) / happy probiotic 50 1.7 65.1 63.4
reg'activ / immune & vitality 1.6 2.9 1.3
genestra brands® hm 0.8 31.2 30.4
spain (es) / profaes4 viajeros 0.8 31.2 30.4
spain (es) / profaes4 edad escolar 0.8 31.2 30.4
amy meyers / primal earth probiotic 0.7 3.3 2.6
microbiome labs /hu58 0.7 3.3 2.6
CustomProbiotics.com / L. Gasseri Probiotic Powder 0.4 5.9 5.5
solgar / advanced multi-billion dophilus 0.4 34.1 33.7
solgar / advanced 40+ acidophilus 0.4 34.1 33.7
jarrow formulas / jarro-dophilus eps 0.2 51 50.8
CustomProbiotics.com / B. Lactis Probiotic Powder 0 5.3 5.3
canada (ca) / calmbiotic 0 8.6 8.6
naturopathica (au) / gastrohealth women’s probiotic with cranberry -0.2 36.3 36.5
spain (es) / suerobivos -0.5 10.1 10.6
culturelle / culturelle -0.5 10.1 10.6
spain (es) / bivos -0.5 10.1 10.6
spain (es) / kaleidon -0.5 10.1 10.6
digestive care -0.5 10.1 10.6
wakamoto (jp) / strong wakamoto w -0.7 4.6 5.3
optibac / for daily immunity -0.7 11.2 11.9
udo's choice /super 8 gold -0.9 73 73.9
CustomProbiotics.com / L. Brevis Probiotic Powder -1.1 0.2 1.3
Nu U (uk) /Bio-Cultures Complex -1.1 32.6 33.7
o'donnell / flora-balance -1.3 1.3 2.6
CustomProbiotics.com / L. Salivarius Probiotic Powder -1.3 4 5.3
organic 3 / gutpro -1.3 60.3 61.6
ASEA VIA / BIOME -1.6 83.8 85.4
CustomProbiotics.com / B. Breve Probiotic Powder -1.9 0.7 2.6
miyarisan (jp) / miyarisan -2.2 3.3 5.5
gnc / ultra probiotic complex -2.5 24.6 27.1
bravo europe / starter and complex -2.4 52.4 54.8
CustomProbiotics.com / B. Infantis Probiotic Powder -2.7 2.6 5.3
spain (es) / alflorex -2.7 2.6 5.3
natren / life start 2 (goat milk-based) -2.7 2.6 5.3
klaire labs / ther-biotic factor 4 -2.7 25.7 28.4
mwsb / candida yeast support -3 10.6 13.6
mutaflor / mutaflor -3.3 2.6 5.9
organic 3 / primal gut -3.5 97.7 101.2
jamieson (can) / probiotic 10 bcfu -3.7 45.8 49.5
seed / female version -3.7 75.9 79.6
quantum wellness / restora flora -3.7 90.9 94.6
Jetson / Gut Prep -4.1 4 8.1
jarrow formulas / jarro-dophilus® ultra -4.1 71.1 75.2
up4 / ultra -4.2 79 83.2
shin biofermin (jp) /s -4.4 20 24.4
natren / healthy trinity probiotic -4.4 20 24.4
nature's bounty / probioti 10 -4.8 44.7 49.5
Seeking Health / Probiota HistaminX -5.1 47.7 52.8
bioflorin (deu) / bioflorin -5.5 4 9.5
renew life / ultimate flora -5.5 82.9 88.4
garden of life / primal defense -5.9 86.5 92.4
solaray / mycrobiome probiotic colon formula -6.2 79.2 85.4
bioglan bio (au) / happy probiotic 100 -6.2 84.9 91.1
CustomProbiotics.com / L. Paracasei Probiotic Powder -6.6 5.3 11.9
naturopathica (au) / gastrohealth antacid -6.6 5.3 11.9
danactive drink -6.6 5.3 11.9
CustomProbiotics.com / L. Casei Probiotic Powder -6.6 9.9 16.5
custom probiotics / five strain bifidobacteria -6.6 21.1 27.7
aor / probiotic-3 -6.9 12.5 19.4
philips / colon health -7.4 20.5 27.9
wakamoto (jp) / wakamoto pharmaceutical intestinal drug -7.4 20.5 27.9
jarrow formulas / fem dophilus -7.7 17.6 25.3
spain (es) / aquilea intimus -7.7 17.6 25.3
blackmore (au) / probiotics+ womens flora balance -7.7 17.6 25.3
optibac / for women -7.7 17.6 25.3
jarrow formulas / fem-dophilus® -7.7 17.6 25.3
klaire labs / target gb-x -8.2 45.3 53.5
nature's way (au) / restore probiotic 100 billion -9.3 100.5 109.8
custom probiotics / b. lactis & b. bifidum probiotic powder -9.9 11.2 21.1
speer labs / emuaid first defense -9.9 24 33.9
ecology_allergycare -10.3 38.5 48.8
renew life men's probiotic - ultimate -10.8 76.3 87.1
douglas laboratories / multi probiotic 40 billion -11.4 82.5 93.9
customprobiotics.com / B. Bifidum Probiotic Powder -11.9 6.6 18.5
natren / bifido factor -11.9 6.6 18.5
spain (es) / gastrus -12.3 9 21.3
spain (es) / reuteri gotas -12.3 9 21.3
spain (es) / casenbiotic -12.3 9 21.3
CustomProbiotics.com / L. Reuteri Probiotic Powder -12.3 9 21.3
spain (es) / gum periobalance -12.3 9 21.3
elixa / probiotic -13.2 86.7 99.9
fürstenmed / lacto-bifido -13.6 71.5 85.1
vita miracle / ultra-30 probiotics -13.6 105.2 118.8
Winclove Probiotics / Ecologic®825 -14.1 66.4 80.5
hyperbiotics / pro-15 -15.4 102.5 117.9
bioray / cytoflora -15.9 84 99.9
fairvital / microflora basic -16 50.2 66.2
newrhythm / probiotics 20 stains -17 103.8 120.8
Jetson (US) / Immunity Probiotics -28 48.8 76.8

No Known Impact

These appear to have no known direct impact. There is no reason to discontinue them if you are talking them

  1. CustomProbiotics.com / L. Bulgaricus Probiotic Powder
  2. CustomProbiotics.com / L. Lactis Probiotic Powder
  3. CustomProbiotics.com / S. Thermophilus Probiotic Powder
  4. goodbelly drink
  5. hyperbiotics / pro-dental
  6. natren / digesta-lac
  7. probiotic 3
  8. symbiopharm / symbioflor 1

Flavonoid Foods Suggested

These are a net positive impact -- Odds are that the dominant flavonoids are what is helping. They may be in other foods that have not been studied. Explore!

Flavonoids Suggested

These are a net positive impact -- see what foods they are in (the higher the better!)

Why "Source: Prefered in bulk and organic, with make your own capsules". First, few pre-capsulized supplements are organic, most have fillers and the cost per gram as prepared capsules can be 4x to 50x higher than in bulk. Many folks have reported things did not help until they change to a different brand with different fillers.

Items to decrease or stop

SubstanceProbability Estimate
thiamine hydrochloride (vitamin B1) 1
vitamin b3 (niacin) 1
Cyanocobalamin (Vitamin B-12) 0.985
retinoic acid (Vitamin A derivative) 0.971
Arbutin (polyphenol) 0.971
diosmin (polyphenol) 0.971
folic acid (supplement Vitamin B9) 0.971
Hesperidin (polyphenol) 0.971
pyridoxine hydrochloride (vitamin B6) 0.971
Guaiacol (polyphenol) 0.971
N-Acetyl Cysteine (NAC) 0.971
caffeine (coffee or non-herbal tea) 0.941
vitamin b7 biotin (supplement) (vitamin B7) 0.941
luteolin (flavonoid) 0.912
melatonin supplement 0.882
Vitamin C (ascorbic acid) 0.882
aspirin (acetylsalicylic acid) 0.765
garlic (allium sativum) 0.338

Contradictory Suggestions

I have seen lactobacillus rhamnosus gg (probiotics) being a TO TAKE and lactobacillus rhamnosus (probiotics) is to avoid. Why? Different studies have different results. Sometimes it is because of other factors (study done on healthy people in one case, on overweight people in the other case). One study may have measured the bacteria you are high in, the other did not. Similarly, one study may have measured the bacteria you are low in, the other did not. There is a forest of qualifications that are nearly impossibly complex to address, and if you try, it will often lack an objective decision that can be demonstrated ("I think...."). Where there are 'conflicts', my usual advice is to just omit it entirely from consideration. If you are taking it, keep taking it. It not, don't.


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