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The information on this site is from academic and research studies. Applicability to humans must be determined by a licensed medical professional.

Suggestions to counter the impact of bosentan (prescription)

US These are suggestions that should be reviewed by a medical professional familar with you before implementing. Some suggestions may have adverse reactions with some conditions. The suggestions are built from a logical model using published research on humans and animals. The suggestions may not be applicable to humans.

Click on the substance to see what it modifies. For probiotic sources click here

Items to increase or take

;
Source: Prefered in bulk and organic, with make your own capsules
SubstanceProbability Estimate
arabinoxylan oligosaccharides (prebiotic) ; 0.552
inulin (prebiotic) ; 0.537
lactulose ; 0.373
ketogenic diet ; 0.343
red wine ; 0.328
pomegranate (fruit, juice etc) ; 0.313

Probiotic Mixtures

See this post on how to add more probiotic mixtures.

As always, probiotics should be reviewed by a knowledgable medical professional before starting.

Positive Impact

These have good impact with NO KNOWN RISK of bad impact. These should be your first choice

  1. symbiopharm / symbioflo 2 : impact 4
  2. nature's way (au) / adult vita gummies daily probiotic 80s : impact 4
  3. align / align : impact 4
  4. source naturals / duraflora : impact 4
  5. thorne / bacillus coagulansvet 60 caps : impact 4
  6. schiff / digestive advantage : impact 4
  7. daiichi sankyo healthcare (jp) / panlacmin tablet : impact 4
  8. spain (es) / lactanza hereditum : impact 2.6
  9. enterogermina : impact 1.3

Mixed Impact

You want the highest NET value (Take - Avoid), when there are several with similar values. Take the one with the lowest avoid value.

Ideally you want Take/Avoid to be a 2:1 or higher ratio.

Commercial Probiotic NameNetTakeAvoid
nature's way (au) /restore probiotic bowel & colon health 30s 40.9 82.5 41.6
naturopathica (au) / gastrohealth probiotic dairy free 50 billion 40.2 93.7 53.5
naturopathica (au) / gastrohealth probiotic dairy free 20 bcfu 37 72.6 35.6
theramedix / probiotic 35.6 103.6 68
nature's way (au) / restore probiotic daily health 90s 32.3 50.8 18.5
nature's way (au) / restore probiotic 30 billion 30s 32.3 50.8 18.5
naturopathica (au) / gastrohealth fibrepro 31.6 45.5 13.9
probiotic pur (de) / realdose nutrition 31 71.3 40.3
blackmore (au) / probiotics+ eczema relief 28.4 40.9 12.5
jarrow formulas / bifidus balance® + fos 27.7 60.7 33
blackmores (au) / probiotics + adults daily (90 capsules) 27.1 56.1 29
blackmore (au) / probiotics+ daily health 27.1 56.1 29
blackmores (au) / probiotics+ immune defence 27.1 63.4 36.3
Realdose 26.4 66.7 40.3
lifted naturals / mood boosting probiotic 22.4 65.3 42.9
up4 /women's 18.5 54.8 36.3
naturopathica (au) / gastrohealth probiotic adults 50+ 17.8 35 17.2
zint nutrition / probiotic collagen + 17.8 48.8 31
custom probiotics / four strain lactobacilli 17.1 47.5 30.4
blackmore (au) / probiotics+ bowel support 16.5 53.5 37
naturopathica (au) /gastrohealth probiotic ultimate daily care 100billion 16.5 61.4 44.9
biospec / probiotic-5 13.2 38.3 25.1
young living/life 9 13.2 66.7 53.5
1 md / complete probiotics platinum 13.2 86.5 73.3
optibac / for those on antibiotics 12.6 21.8 9.2
optibac / for every day 12.5 57.4 44.9
vinco / probiotic eight 65 12.5 62.7 50.2
seed / male version 11.8 65.3 53.5
optibac / for every day max 11.2 25.1 13.9
spain (es) / l3.1 10.5 29 18.5
optibac / bifidobacteria & fibre 9.9 33 23.1
jarrow formula / jarro-dophilus original 9.9 60.7 50.8
nature's instincts / ultra spore probiotic 9.2 12.5 3.3
quality health(au)/ fridge free probiotic 25b 9.3 20.5 11.2
optibac / for your cholesterol 9.2 26.4 17.2
custom probiotics / d-lactate free probiotics powder 9.2 27.7 18.5
spain (es) / vivomixx 9.2 50.8 41.6
up4 / adult 9.2 54.1 44.9
visbiome 9.2 55.4 46.2
custom probiotics / six strain probiotic powder 9.2 58.7 49.5
bioglan bio (au/ happy probiotic 25 8.6 18.5 9.9
bioglan (au) / healthy kids probiotic choc balls 50s 8.6 18.5 9.9
nature's way (au) / restore probiotic choc balls 60s 8.6 18.5 9.9
solgar / advanced acidophilus plus 8.6 18.5 9.9
spain (es) / ns defenbiotic kids 8.6 20.5 11.9
spain (es) / ultralevura 8 10.6 2.6
spain (es) / axiboulardi 8 10.6 2.6
natren / megadophilus 7.9 13.2 5.3
quality health (au) / fridge free* probiotic 60s 7.9 13.2 5.3
naturopathica (au)/ gastrohealth probiotic daily care 7.9 21.1 13.2
bio-k+ 7.3 31.7 24.4
ferring / vsl#3 7.2 47.5 40.3
bioglan bio (au) / happy probiotic 50 7.2 64 56.8
microbiome labs / restorflora 6.6 9.9 3.3
florastor / florastor 5.9 6.6 0.7
optibac / saccharomyces boulardii 5.9 6.6 0.7
organic 3 / yeastbiotic 5.9 6.6 0.7
bayer / trubiotics daily probiotic 6 13.9 7.9
trubiotics / one a day 6 13.9 7.9
jarrow formulas / jarro-dophilus mood 6 17.2 11.2
cytoplan(uk) /dentavital bifidophilus 6 38.3 32.3
udo's choice /super 8 gold 5.9 71.9 66
microbiome labs/ megasporebiotic 5.2 9.2 4
spain (es) / muvagyn probiotico 5.3 14.5 9.2
anabolic laboratories / probiotic complete 5.2 15.8 10.6
spain (es) / ns florabiotic instant 5.3 18.5 13.2
bravo europe / freeze-dried bravo 5.3 31.7 26.4
just for tummies / live bacteria 5.2 32.3 27.1
organic 3 / primal gut 5.3 96.4 91.1
jarrow formula / ideal bowel support® lp299v® 4.6 21.8 17.2
organic 3 / gutpro 4.6 59.4 54.8
quantum wellness / restora flora 4.7 89.8 85.1
activia drink 4 11.9 7.9
Nu U (uk) /Bio-Cultures Complex 4 31.7 27.7
solgar / advanced multi-billion dophilus 4 33.7 29.7
solgar / advanced 40+ acidophilus 4 33.7 29.7
jarrow formulas / jarro-dophilus eps 4 50.2 46.2
vitamin angels / just thrive 3.3 5.9 2.6
organic 3 / primal soil 3.3 5.9 2.6
reserveage nutrition / beautiflora 3.3 5.9 2.6
enviromedica terraflora sbo probiotic 3.3 5.9 2.6
corebiotic 3.3 5.9 2.6
klaire labs / biospora 3.3 5.9 2.6
perfect pass / perfect pass probiotic bacillus spore 3.3 5.9 2.6
global health trax / threelac 3.3 5.9 2.6
bio-botanical research / proflora4r restorative probiotic 3.3 5.9 2.6
powerlabs (au) / ultra blend 3.3 19.8 16.5
genestra brands® hm 3.3 31 27.7
spain (es) / profaes4 viajeros 3.3 31 27.7
spain (es) / profaes4 edad escolar 3.3 31 27.7
naturopathica (au) / gastrohealth women’s probiotic with cranberry 3.3 33.7 30.4
bravo europe / starter and complex 3.3 52.1 48.8
jarrow formulas / jarro-dophilus® ultra 3.3 70 66.7
up4 / ultra 3.3 77.9 74.6
renew life / ultimate flora 3.3 81.8 78.5
seed / female version 2.7 70 67.3
solaray / mycrobiome probiotic colon formula 2.7 77.9 75.2
bioglan bio (au) / happy probiotic 100 2.6 83.8 81.2
garden of life / primal defense 2.6 85.1 82.5
nature's way (au) / restore probiotic 100 billion 2.7 96.4 93.7
naturopathica (au) / gastrohealth probiotics 2 4 2
reg'activ / immune & vitality 1.3 2.6 1.3
canada (ca) / calmbiotic 1.3 8.6 7.3
jamieson (can) / probiotic 10 bcfu 1.3 45.5 44.2
amy meyers / primal earth probiotic 0.7 3.3 2.6
microbiome labs /hu58 0.7 3.3 2.6
wakamoto (jp) / strong wakamoto w 0.6 4.6 4
spain (es) / suerobivos 0.7 9.9 9.2
culturelle / culturelle 0.7 9.9 9.2
spain (es) / bivos 0.7 9.9 9.2
spain (es) / kaleidon 0.7 9.9 9.2
digestive care 0.7 9.9 9.2
gnc / ultra probiotic complex 0 24.4 24.4
klaire labs / ther-biotic factor 4 0 25.7 25.7
nature's bounty / probioti 10 0 44.2 44.2
miyarisan (jp) / miyarisan -0.7 3.3 4
optibac / for daily immunity -0.7 9.9 10.6
mwsb / candida yeast support -0.7 9.9 10.6
vita miracle / ultra-30 probiotics -0.6 101 101.6
o'donnell / flora-balance -1.3 1.3 2.6
renew life men's probiotic - ultimate -2 75.2 77.2
spain (es) / alflorex -2.7 2.6 5.3
natren / life start 2 (goat milk-based) -2.7 2.6 5.3
shin biofermin (jp) /s -2.6 19.8 22.4
natren / healthy trinity probiotic -2.6 19.8 22.4
douglas laboratories / multi probiotic 40 billion -2.6 81.2 83.8
elixa / probiotic -2.6 83.2 85.8
mutaflor / mutaflor -3.3 2 5.3
klaire labs / target gb-x -3.3 44.9 48.2
bioflorin (deu) / bioflorin -3.9 4 7.9
custom probiotics / five strain bifidobacteria -4 21.1 25.1
Winclove Probiotics / Ecologic®825 -3.9 64.7 68.6
hyperbiotics / pro-15 -4 99 103
aor / probiotic-3 -4.7 12.5 17.2
naturopathica (au) / gastrohealth antacid -5.3 5.3 10.6
danactive drink -5.3 5.3 10.6
jarrow formulas / fem dophilus -5.3 15.2 20.5
spain (es) / aquilea intimus -5.3 15.2 20.5
blackmore (au) / probiotics+ womens flora balance -5.3 15.2 20.5
optibac / for women -5.3 15.2 20.5
jarrow formulas / fem-dophilus® -5.3 15.2 20.5
philips / colon health -5.2 20.5 25.7
wakamoto (jp) / wakamoto pharmaceutical intestinal drug -5.2 20.5 25.7
fürstenmed / lacto-bifido -5.3 70.6 75.9
bioray / cytoflora -6 80.5 86.5
speer labs / emuaid first defense -6.6 23.8 30.4
newrhythm / probiotics 20 stains -6.6 97.7 104.3
custom probiotics / b. lactis & b. bifidum probiotic powder -7.9 11.2 19.1
fairvital / microflora basic -9.2 46.9 56.1
spain (es) / gastrus -9.9 6.6 16.5
spain (es) / reuteri gotas -9.9 6.6 16.5
spain (es) / casenbiotic -9.9 6.6 16.5
spain (es) / gum periobalance -9.9 6.6 16.5
natren / bifido factor -10.6 6.6 17.2

No Known Impact

These appear to have no known direct impact. There is no reason to discontinue them if you are talking them

  1. goodbelly drink
  2. hyperbiotics / pro-dental
  3. natren / digesta-lac
  4. probiotic 3
  5. symbiopharm / symbioflor 1

Flavonoid Foods Suggested

These are a net positive impact -- Odds are that the dominant flavonoids are what is helping. They may be in other foods that have not been studied. Explore!

Flavonoids Suggested

These are a net positive impact -- see what foods they are in (the higher the better!)

Why "Source: Prefered in bulk and organic, with make your own capsules". First, few pre-capsulized supplements are organic, most have fillers and the cost per gram as prepared capsules can be 4x to 50x higher than in bulk. Many folks have reported things did not help until they change to a different brand with different fillers.

Items to decrease or stop

SubstanceProbability Estimate
thiamine hydrochloride (vitamin B1) 1
vitamin b3 (niacin) 1
Cyanocobalamin (Vitamin B-12) 0.985
retinoic acid (Vitamin A derivative) 0.97
diosmin (polyphenol) 0.97
folic acid (supplement Vitamin B9) 0.97
Hesperidin (polyphenol) 0.97
Arbutin (polyphenol) 0.97
pyridoxine hydrochloride (vitamin B6) 0.97
Guaiacol (polyphenol) 0.97
N-Acetyl Cysteine (NAC) 0.97
vitamin b7 biotin (supplement) (vitamin B7) 0.955
caffeine (coffee or non-herbal tea) 0.94
luteolin (flavonoid) 0.91
melatonin supplement 0.881
aspirin (acetylsalicylic acid) 0.761
garlic (allium sativum) 0.313

Contradictory Suggestions

I have seen lactobacillus rhamnosus gg (probiotics) being a TO TAKE and lactobacillus rhamnosus (probiotics) is to avoid. Why? Different studies have different results. Sometimes it is because of other factors (study done on healthy people in one case, on overweight people in the other case). One study may have measured the bacteria you are high in, the other did not. Similarly, one study may have measured the bacteria you are low in, the other did not. There is a forest of qualifications that are nearly impossibly complex to address, and if you try, it will often lack an objective decision that can be demonstrated ("I think...."). Where there are 'conflicts', my usual advice is to just omit it entirely from consideration. If you are taking it, keep taking it. It not, don't.


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